Scientific Program
To view some of the presentations that were given at the ICSG2011 meeting please click the name of the speaker. Please note: this will only work for speakers that have provided us with a copy of their presentation. |
| Tuesday May 10, 2011 |
Pre-conference Workshops, University of Toronto |
| 9:00 am - 4:00 pm |
Small Molecule Screening |
| 9:00 am - 3:00 pm |
Eukaryotic Gene Expression Systems |
| 9:00 am - 4:00 pm |
Workshop on NMR Methods for Structural Biology |
| 9:00 am - 3:00 pm |
iSee: Interactive 3D Documents for the Dissemination of Structural Biology |
| 8:30 am - 4:00 pm |
Phenix Crystallography Software |
Tuesday May 10, 2011 |
89 Chestnut Conference Centre |
| 2:00 - 5:00 pm |
Registration |
|
| 5:00 - 5:15 pm |
Welcome and Introductory Remarks
Cheryl Arrowsmith (Structural Genomics Consortium - Toronto, Toronto, ON, Canada)
|
| 5:15 - 6:00 pm |
Plenary Lecture 1
Ray Stevens (The Scripps Research Institute, La Jolla, CA, USA)
Structure and Function of the Human GPCR Superfamily
|
| 6:00 - 6:45 pm |
Plenary Lecture 2
Natalie Strynadka (University of British Columbia, BC, Canada)
Structure-based analysis of protein transport across bacterial membranes
|
| 7:00 - 9:00 pm |
Welcome Reception |
|
Wednesday May 11, 2011 |
89 Chestnut Conference Centre |
8:30 - 10:30 am
8:30 am
8:55 am
9:20 am
9:45 am
10:00 am
|
Session 1 - Advances in protein expression, purification and crystallization
Chair: Geoffrey Waldo (Los Alamos National Laboratories, Los Alamos, NM, USA)
Anthony Kossiakoff (University of Chicago, Chicago, IL, USA)
Chaperone-Enabled Biology-Structure Technology Platform
Par Nordlund (Karolinska Institutet, Stockholm, Sweden)
Understanding specificity and mechanism in human nucleotide metabolism and lipid signaling pathways
Jennifer L Martin (University of Queensland, Brisbane, Queensland, Australia)
Structure and function studies of macrophage proteins using the UQSG pipeline
Jan Steyaert (Vrije Universiteit Brussel, Burssel, Belgium)
Conformation selective nanobodies for GPCR research
Cristina Viola (EMBL Grenoble, Grenoble, France)
Expression strategies for protein complex production
|
| 10:30 am |
Break/Vendor Booths |
11:00 - 1:00 pm
11:00 am
11:25 am
11:50 am
12:15 pm
12:30 pm
|
Session 2: Structural Genomics of Integral Membrane Proteins
Chair: Gil Prive (University Health Network / University of Toronto, Toronto, ON, Canada)
Wayne Hendrickson (Columbia University, New York, NY, USA)
Membrane Protein Structures from a Structural Genomics Approach
Robert Stroud (University of California San Francisco, San Francisco, CA, USA)
Approaches to the Structures of Eukaryotic Membrane Proteins
Liz Carpenter (Structural Genomics Consortium - Oxford, Oxford, UK)
Human integral membrane protein structural biology at the SGC
Oliver P. Ernst (University of Toronto, Toronto, ON, Canada)
Crystal structure of metarhodopsin II
Isabel Moraes (Imperial College, London, UK)
Challenges and Opportunities in Structure Determination of Membrane Proteins
|
| 1:00 pm |
Lunch/Vendor Booths |
2:30 - 4:00 pm
2:30 pm
2:55 pm
3:20 pm
3:45 pm
|
Session 3: Infectious Disease Research I: Viral and Parasitic Diseases
Chair: James C Sacchettini (Texas A&M University, College Station, TX, USA)
Raymond Hui (Structural Genomics Consortium, Toronto, ON, Canada)
Using Structural Genomics to Study Druggable Targets in Protozoan Parasites
David Stuart (University of Oxford, Oxford, UK)
Methods for highish throughput crystallography applied to infectious and non-infectious virus particles
Bruno Coutard (AFMB, CNRS, Marseille, France)
Structural Genomics on viral replicative machinery: A tool for antiviral discovery
Johannes Bauer (University of Tuebingen, Tuebingen, Germany)
The GD1A Glycan is a Cellular Receptor for Adenoviruses Causing Epidemic Keratoconjunctivitis
|
| 4:00 pm |
Break/Vendor Booths |
4:30 - 6:00 pm
4:30 pm
4:55 pm
5:20 pm
5:45 pm
|
Session 4: Automated and Advanced Techniques for Protein Structure Determination
Chair: Udo Heinemann (Max-Delbrück Center for Molecular Medicine, Berlin, Germany)
Thomas Terwilliger (Los Alamos National Laboratory, Los Alamos, NM, USA)
X-ray crystal structure determination with PHENIX and Rosetta
Thomas Szyperski (State University of New York at Buffalo, Buffalo, NY, USA)
Development and Application of NMR Methodology for HTP Protein Structure Determination
Wladek Minor (University of Virginia, Charlottesville, VA, USA)
HKL-3000: Toward the Future of Structural Biology
Patrick Shaw Stewart (Douglas Instruments Ltd., Berkshire, UK)
Random microseeding: a theoretical and practical exploration of the Microseed Matrix Screening (MMS) method, with new recommendations for achieving crystallization success.
|
| 6:00 - 7:30 pm |
Poster Session 1 |
|
Thursday May 12, 2011 |
89 Chestnut Conference Centre |
8:30 - 10:30 am
8:30 am
8:55 am
9:20 am
9:45 am
10:10 am
|
Session 5: Structure-Enabled Biology
Chair: Ward Smith (NIH/NIGMS, Bethesda, MD, USA)
Ian A. Wilson (The Scripps Research Institute, La Jolla, CA, USA)
High Throughput Structural Biology Applied to Challenging Biological Systems
Dino Moras (Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France)
The Role of DNA in Transcription Regulation by Nuclear Receptors: An Integrated Structural Biology Approach
Shigeyuki Yokoyama (RIKEN Systems and Structural Biology Center, Kanagawa, Japan)
Structural Basis for Specific Aminoacyl-tRNA Synthesis
Yunyu Shi (University of Science and Technology of China, Hefei, China)
Structural basis of epigenetic regulation
Fumiaki Yumoto (University of California, San Francisco, San Francisco, CA, USA)
Structural insight into transcriptional coactivation of LRH-1 by beta-catenin
|
| 10:30 am |
Break/Vendor Booths |
11:00 - 1:00 pm
11:00 am
11:25 am
11:50 am
12:15 pm
12:30 pm
|
Session 6: Structure Enabled Understanding of Signaling Networks & Systems Biology
Chair: Helen Berman (Rutgers University, Piscataway, NJ, USA)
Titia Sixma (Netherlands Cancer Institute, Amsterdam, The Netherlands)
Regulation of ubiquitin specific proteases
Frank Sicheri (Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada)
Structural principles of signal transduction
Lucia Banci (University of Florence, Florence, Italy)
Mechanistic Systems Biology: from structures to functional pathways
Fuyuhiko Inagaki (Hokkaido University, Sapporo, Japan)
Structural Biology of Selective Autophagy
John R. Cort (Pacific Northwest National Laboratory, Richland WA, USA)
Structural and Functional Characterization of Pathogen Effector—Host Protein Interactions
|
| 1:00 pm |
Lunch/Vendor Booths |
2:30 - 4:00 pm
2:30 pm
2:55 pm
3:20 pm
3:35 pm
|
Session 7: Structural Genomics and Drug Discovery I
Chair: Stephen Burley (Lilly Biotechnology Center, San Diego, CA, USA)
James C Sacchettini (Texas A&M University, College Station, TX, USA)
Antimicrobial Drug Discovery and Structural Genomics
Steven Almo (Albert Einstein College of Medicine, Bronx, NY, USA)
Sequence, Structure, Function, Immunity
Ekaterina Kouznetsova (Structural Genomics Consortium - Stockholm, Stockholm, Sweden)
Crystal structures of human tankyrase in complex with novel inhibitors
Guido Hansen (University of Lübeck, Lübeck, Germany)
Structural biology on Legionella
|
| 4:00 pm |
Break/Vendor Booths |
4:30 - 6:00 pm
4:30 pm
4:55 pm
5:20 pm
5:35 pm
|
Session 8: Hybrid Methods and Macromolecular Complexes
Chair: Imre Berger (EMBL, Grenoble France)
Andrej Sali (University of California San Francisco, San Francisco, CA, USA)
Determining architectures of macromolecular assemblies by aligning interaction networks to electron microscopy density maps
John A. Tainer (The Scripps Research Institute, La Jolla, CA, USA)
Accurate structures, conformations, and assemblies of macromolecules in solution by high throughput X-ray scattering (SAXS) combined with crystallography
Pedro Serrano (Joint Center for Structural Genomics, La Jolla, CA, USA)
New strategy for the use of NMR spectroscopy in the crystallography-centric Joint Center for Structural Genomics
Michael Plevin (Institut de Biologie Structurale, Grenoble, France)
SeSEAM: a Systematic Mutagenesis-Driven Strategy for Site-Resolved NMR Studies of Supramolecular Assemblies
|
| 6:00 - 7:30 pm |
Poster Session 2 |
|
Friday May 13, 2011 |
89 Chestnut Conference Centre |
8:30 - 10:30 am
8:30 am
8:55 am
9:20 am
9:45 am
10:00 am
|
Session 9: Infectious Disease Research II: Bacterial Diseases
Chair: Wayne Anderson (Northwestern University, Chicago, IL, USA)
Peter J Myler (Seattle Biomedical Research Institute, Seattle, WA)
Wayne Anderson (Northwestern University, Chicago, IL, USA)
Structural Genomics to aid drug discovery for infectious diseases
Edward N. Baker (University of Auckland, Auckland, New Zealand)
Structure and assembly of bacterial pili, from analysis of virulence-related gene clusters
Peter J Myler (Seattle Biomedical Research Institute, Seattle, WA)
Three Hundred New Protein Structures from Microbial Pathogens
Bridget Mabbutt (Macquarie University, Sydney, Australia)
Plasticity of Vibrio and A. baumanii genomes: structural genomics for mobile gene functions
Alexei Savchenko (University of Toronto, Toronto, ON, Canada)
Structural insight into the function of effector proteins – bacterial pathogenic factors orchestrating eukaryotic cell biology
|
| 10:30 am |
Break/Vendor Booths |
11:00 - 1:00 pm
11:00 am
11:25 am
11:50 am
12:15 pm
12:30 pm
|
Session 10: Advanced and Automated Methods in Structural Biology and Structural Genomics
Chair: George T. DeTitta (SUNY at Buffalo, Buffalo, NY, USA)
Soichi Wakatsuki (High Energy Accelerator Research Organization (KEK), Tsukuba, Japan)
Beamline developments for targeted structural proteomics
Lewis E. Kay (University of Toronto, Toronto, ON, Canada)
Seeing the Invisible by Solution NMR Spectroscopy
Andrzej Joachimiak (Argonne National Laboratory, Argonne, IL, USA)
Human Microbiome - the Next Structural Frontier
James Fraser (University of California San Francisco, San Francisco, CA, USA)
Crystal freezing quenches protein motions and biases hydrophobic packing
Giuseppe Melacini (McMaster University, Hamilton, ON, Canada)
Understanding Signaling Networks through the Covariance Analysis of NMR Chemical Shifts
|
| 1:00 pm |
Lunch/Vendor Booths |
2:00 - 3:30 pm
2:00 pm
2:25 pm
2:50 pm
3:05 pm
|
Session 11: Computational Approaches to Structure and Function
Chair: Brian Marsden (University of Oxford, Oxford, UK)
Shoshana J. Wodak (University of Toronto, Toronto, ON, Canada)
Protein-protein interactions: predicting the structure of complexes and their interfaces
Adam Godzik (Sanford-Burnham Medical Research Institute, La Jolla, CA)
TBD
Joel L. Sussman (Weizmann Institute of Science, Rehovot, Israel)
Proteopedia - a Scientific ‘Wiki’ Bridging the Rift Between 3D Structure and Function of Biomacromolecules
Alexey G. Murzin (MRC Laboratory of Molecular Biology, Cambridge, UK)
Structure shortcuts to function prediction
|
| 3:30 pm |
Break/Vendor Booths |
4:00 - 5:30 pm
4:00 pm
4:25 pm
4:50 pm
5:05 pm
|
Session 12: Functional Genomics
Chair: Opher Gileadi (Structural Genomics Consortium - Oxford, Oxford, UK)
Gaetano T. Montelione (Rutgers University, Piscataway. NJ, USA)
TBD
John L Markley (University of Wisconsin–Madison, Madison, WI, USA)
Automated approaches to protein NMR assignment and structure determination
Akeo Shinkai (RIKEN SPring-8 Center, Sayo, Japan)
Structural and functional genomics of a model organism Thermus thermophilus HB8: toward functional discovery of functionally unknown proteins
Allan Matte (National Research Council Canada, Montreal, QC, Canada)
Structural Proteomics of Bacterial Protein Complexes at the BSGI
|
| 7:00 - 1:00 am |
Banquet – CN Tower |
Saturday May 14, 2011 |
89 Chestnut Conference Centre |
9:00 - 10:30 am
9:00 am
9:25 am
9:50 am
|
Session 13: Structural Genomics and Drug Discovery II
Chair: Pierre Meulien (Genome Canada, Ottawa, ON, Canada)
Stephen Burley (Eli Lilly and Company, San Diego, CA, USA)
Challenges in Fragment Based Structure Guided Drug Discovery
Stefan Knapp (Structural Genomics Consortium - Oxford, Oxford University, UK)
Targeting Phosphorylation Signalling Networks
William Zuercher (GSK, Research Triangle Park, NC, USA)
The Published Kinase Inhibitor Set: A resource to develop probes for the untargeted kinome
|
|
10:30 - 11:15 am
|
Closing Lecture
Aled Edwards (Structural Genomics Consortium, Toronto, ON, Canada)
Structural genomics: Opportunities to drive biology
|
|
11:15 - 11:30 am
|
Closing Remarks
Cheryl Arrowsmith (Structural Genomics Consortium - Toronto, Toronto, ON, Canada)
|
Saturday May 14, 2011 |
Post Conference |
| 12:00 pm |
Tour of the Niagara Region (Additional Registration Required)
Departing from 89 Chestnut
|
|
