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STRUCTURE OF THE MONTH

The EphB4 isoform is especially important biomedically as it is overexpressed in multiple types of tumors, where its expression levels are often correlated with increased malignancy, possibly by promoting angiogenesis. It has an intriguing role in breast cancer, where it has both tumor-suppressing and tumor-promoting activities.

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PUBLICATION OF THE MONTH

Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, M´┐Żller S, Sobott F, Parker SA, Zhang H, Min W, Turk BE, Knapp S.
Structural and Functional Characterization of the Human Protein Kinase ASK1.
Structure. 2007 Oct;15(10):1215-26.

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