STRUCTURES SOON TO BE RELEASEDRSS
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Human SH3 domain of LIM and SH3 domain protein 1
PDB: 3I35
2009-06-30 -
human Homo sapiens heat shock 70kDa protein 2 (HSPA2)
PDB: 3I33
2009-06-30
SGC NEWSRSS
- 2008-12-18 - Wellcome Trust Funds SGC-led Public-Private Partnership to Develop Chemical Probes for Drug Discovery
- 2008-11-10 - SGC and OICR Host Symposium on Chemical Biology-Based Drug Design in Toronto
- 2008-08-30 - Visiting Scientist Program
STRUCTURE OF THE MONTH
The EphB4 isoform is especially important biomedically as it is overexpressed in multiple types of tumors, where its expression levels are often correlated with increased malignancy, possibly by promoting angiogenesis. It has an intriguing role in breast cancer, where it has both tumor-suppressing and tumor-promoting activities.
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PUBLICATION OF THE MONTH
Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, M�ller S, Sobott F, Parker SA, Zhang H, Min W, Turk BE, Knapp S.
Structural and Functional Characterization of the Human Protein Kinase ASK1.
Structure. 2007 Oct;15(10):1215-26.
