Group Publications

2011

Characterization of a new phosphatase from Plasmodium.
Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC
Mol. Biochem. Parasitol.. 13.06.2011 179(2):69-79. doi: 10.1016/j.molbiopara.2011.06.001
PMID: 21689687

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.
Mariño K, Güther ML, Wernimont AK, Qiu W, Hui R, Ferguson MA
Eukaryotic Cell. 29.04.2011 10(7):985-97. doi: 10.1128/EC.05025-11
PMID: 21531872

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R
J. Biol. Chem.. 04.02.2011 286(5):3315-22. doi: 10.1074/jbc.M109.027235
PMID: 21084289

2010

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.
Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD
Cell Host Microbe. 16.12.2010 8(6):484-95. doi: 10.1016/j.chom.2010.11.005
PMID: 21147463

Structures of parasitic CDPK domains point to a common mechanism of activation.
Wernimont AK, Amani M, Qiu W, Pizarro JC, Artz JD, Lin YH, Lew J, Hutchinson A, Hui R
Proteins. 03.12.2010 79(3):803-20. doi: 10.1002/prot.22919
PMID: 21287613

The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum.
El Bakkouri M, Pow A, Mulichak A, Cheung KL, Artz JD, Amani M, Fell S, de Koning-Ward TF, Goodman CD, McFadden GI, Ortega J, Hui R, Houry WA
J. Mol. Biol.. 03.12.2010 404(3):456-77. doi: 10.1016/j.jmb.2010.09.051
PMID: 20887733

The crystal structure of Toxoplasma gondii pyruvate kinase 1.
Bakszt R, Wernimont A, Allali-Hassani A, Mok MW, Hills T, Hui R, Pizarro JC
PLoS ONE. 14.09.2010 5(9):e12736. doi: 10.1371/journal.pone.0012736
PMID: 20856875

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase.
Mariño K, Güther ML, Wernimont AK, Amani M, Hui R, Ferguson MA
Glycobiology. 19.08.2010 20(12):1619-30. doi: 10.1093/glycob/cwq115
PMID: 20724435

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.
Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD
Nature. 20.05.2010 465(7296):359-62. doi: 10.1038/nature09022
PMID: 20485436

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.
Wernimont AK, Artz JD, Finerty P, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R
Nat. Struct. Mol. Biol.. 02.05.2010 17(5):596-601. doi: 10.1038/nsmb.1795
PMID: 20436473

Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector.
Hliscs M, Sattler JM, Tempel W, Artz JD, Dong A, Hui R, Matuschewski K, Schüler H
J. Biol. Chem.. 09.04.2010 285(15):11572-83. doi: 10.1074/jbc.M109.054916
PMID: 20083609

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG
Nature. 01.04.2010 464(7289):728-32. doi: 10.1038/nature08893
PMID: 20360736

2009

Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide.
Alag R, Bharatham N, Dong A, Hills T, Harikishore A, Widjaja AA, Shochat SG, Hui R, Yoon HS
Protein Sci.. 20.08.2009 18(10):2115-24. doi: 10.1002/pro.226
PMID: 19691130

Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis.
Sibley LD, Qiu W, Fentress S, Taylor SJ, Khan A, Hui R
Eukaryotic Cell. 22.05.2009 8(8):1085-93. doi: 10.1128/EC.00107-09
PMID: 19465561

Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands.
Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ, Castaneda LJ, Bhandari J, Damman CJ, Hui R, Hol WG, Buckner FS, Verlinde CL, Zhang Z, Fan E, van Voorhis WC
J Biomol Screen. 21.05.2009 14(6):700-7. doi: 10.1177/1087057109335749
PMID: 19470714

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii.
Qiu W, Wernimont A, Tang K, Taylor S, Lunin V, Schapira M, Fentress S, Hui R, Sibley LD
EMBO J.. 08.04.2009 28(7):969-79. doi: 10.1038/emboj.2009.24
PMID: 19197235

2008

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.
Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R
Chem. Biol.. 22.12.2008 15(12):1296-306. doi: 10.1016/j.chembiol.2008.10.017
PMID: 19101474

2007

Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.
Dufe VT, Qiu W, Müller IB, Hui R, Walter RD, Al-Karadaghi S
J. Mol. Biol.. 12.10.2007 373(1):167-77. doi: 10.1016/j.jmb.2007.07.053
PMID: 17822713

A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.
Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, Kotra LP
J. Med. Chem.. 08.03.2007 50(5):915-21. doi: 10.1021/jm060827p
PMID: 17290979

2006

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R
Mol. Biochem. Parasitol.. 13.11.2006 151(1):100-10. doi: 10.1016/j.molbiopara.2006.10.011
PMID: 17125854

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