Structural Genomics Consortium - University of Toronto

The SGC works with a number of scientists around the globe to

elucidate the functional implications of our structures and protein targets in general,
screen our protein targets against our collaborators' focused libraries,
take advantage of external expertise to characterize the activity of our proteins,
extend our understanding of our protein families of interest,
collaborate on expressing our proteins and reaching structural solutions more expediently,
develop "open access" reagents including chemical probes and recombinant renewable affinity reagents to epigenetic targets.

Our collaborations can be categorised as follows (click on each to see current collaborations):

STRATEGIC COLLABORATORS

Ongoing

Dr. James Bradner, Broad Institute of MIT and Harvard
Dr. James Inglese, NIH Chemical Genomics Center: PMID 20451379, 20017496
Dr. Wladek Minor, University of Virginia: PMID 19101474
Dr. David Wishart, University of Alberta
Dr. Adelinda Yee and Dr. Ryan Dougherty, Ontario Centre for Structural Proteomics
Dr. Andrei Yudin, University of Toronto

Completed

Dr. Michael Maguire, Case Western Reserve University
Dr. Anne Mulichak, Dr. Kevin Battaile and Dr. Lisa Keefe, IMCA-CAT Argonne National Laboratory
Dr. Andrezej Joachimiak, Argonne National Laboratory

BIOPHYSICS

Ongoing

BIOTECHNOLOGY

Ongoing

CELL SIGNALLING AND METABOLISM

Ongoing

Dr. David Andrews, McMaster University
Dr. Douglas Auld, Dr. Craig Thomas, NIH Chemical Genomics Center: PMID 20451379, 20017496
Dr. Matthias Buck, Case Western Reserve University: PMID 17916560, 19843518
Dr. Athar Chishti, University of Illinois: PMID 21057110
Dr. Suzanne Jackowski, St. Jude Childrens Hospital: PMID 17631502, 16905099
Dr. Glenville Jones, Queen's University: PMID 18511070
Dr. Michel Leroux, Simon Fraser University: PMID 20207729
Dr. Charles Rock, St. Jude Childrens Hospital: PMID 17631502, 16905099
Prof. Sergey Usanov, National Academy of Sciences of Belarus: PMID 21636783, 18511070, 20149798 and in Vitamin D: Nutrition, Side Effects and Supplements (Nova Publishers)

CHROMATIN BIOLOGY AND EPIGENETICS

Ongoing

Completed

Dr. Frederic Chedin , University of California, Davis: PMID 18538573
Dr. John Denu, University of Wisconcin: PMID 21362626
Dr. Thomas McClean, Broad Institute of MIT and Harvard, Chemical Biology Program: PMID 18285338
Dr. Rolf Sternglanz, Stony Brook University: PMID 17355872
Dr. Jerry Workman, Stowers Institute for Medical Research: PMID 21685874

CHEMICAL PROBES FOR EPIGENETICS

Ongoing

Dr. Rima Al-awar, Ontario Institute for Cancer Research
Dr. Assam El-Osta and Dr. Guy Krippner , Baker IDI Heart and Diabetes Institute
Dr. James Ellis, Hospital for Sick Children: PMID 21743462
Dr. Stephen Frye, University of North Carolina at Chapel Hill: PMID 21743462, 21417280, 20614940, 20659682, 20008215, 19891491
Dr. Benjamin Garcia, Princeton University: PMID 21743462
Prof. William Janzen, University of North Carolina at Chapel Hill: PMID 21743462, 21417280, 20614940, 20659682, 20008215
Dr. Jian Jin, University of North Carolina at Chapel Hill: PMID 21743462, 21417280, 20614940, 20659682, 19891491
Dr. Arturas Petronis, Centre for Adiction and Mental Health: PMID 21743462
Dr. Anton Simeonov, NIH Chemical Genomics Center: PMID 20614940, 20567762, 19891491
Dr. Timothy Willson, GlaxoSmithKline: PMID 19536100

INFORMATICS

Ongoing

Completed

UBIQUITIN BIOLOGY/DIABETES

Ongoing

Dr. Charles Brenner, University of Iowa: PMID 21389349
Dr. Christian Bronner, Université Louis Pasteur: PMID 21489993, 21643543, 18772889
Dr. Frederic Chedin, University of California, Davis: PMID 21489993, 21643543
Dr. Walter Chazin, Vanderbilt University: PMID 21518764
Dr. Nathaniel Gray, Dana Farber Cancer Institute: PMID 19553108
Dr. Benedikt Kessler, University of Oxford: PMID 18954305
Dr. Martin Lackmann, Monash University: PMID 20505120
Dr. Benjamin Nicholson, Progenra Inc.
Dr. Brian Raught, University Health Network: PMID 21084285
Dr. Vivian Saridakis, York University: PMID 21084285
Dr. Aaron Schimmer, Ontario Cancer Institute: PMID 20075161, 20368332
Dr. Yi Sheng, York University: PMID 21084285
Dr. Frank Sicheri, Samuel Lunenfeld Research Institute: PMID 21683433
Dr. Robert Stahelin, Indiana University School of Medicine, South Bend
Dr. Ben Turk, Yale: PMID 19028587, 19678838

Completed

Dr. Christian Cambillau, Aix-Marseille Université: PMID 18702514
Dr. Frederic Carriere, Laboratoire de Lipolyse Enzymatique, CNRS, Marseille: PMID 18702514
Dr. Peter Davies, Queens University: PMID 19215300
Dr. Elan Eisenmesser, University of Colorado: PMID 20676357, 18397323
Dr. Weontae Lee, Yonsei University: PMID 20826778
Dr. Dimitar Nikolov, Sloan-Kettering Institute: PMID 20505120
Dr. Robert Piper, University of Iowa: PMID 19887378
Dr. Yi-Min She, Health Canada, Ottawa: PMID 16973127, 20405931
Dr. Deborah Thompson, University of Michigan: PMID 190287587
Dr. Ho-Sup Yoon, Nanyang Technological University: PMID 20724435, 20360736

PARASITOLOGY

Ongoing

Dr. Michael Ferguson, University of Dundee: PMID 20724435, 20360736
Dr. Walid Houry, University of Toronto
Dr. Kevin Kain, McLaughlin Center for Molecular Medicine: PMID 21689687, 17290979, 17125854
Dr. Lakshmi Kotra, University Health Network: PMID 17290979
Dr. Kai Matuschewski, Max Planck Institute for Infection Biology: PMID 20083609
Dr. Emil Pai , University of Toronto: PMID 17290979
Dr. David Roos , PlasmoDB, University of Pennsylvania: PMID 17125854
Dr. Kevan Shokat, University of California, San Francisco
Dr. David Sibley, University of Washington, St. Louis: PMID 20436473, 19465561, 19197235
Dr. Andrew Waters, University of Glasgow: PMID 21689687
Dr. Paul Wyatt, University of Dundee: PMID 20360736
Dr. Ho-Sup Yoon, Nanyang Technological University: PMID 19691130

Completed

TRANSFERASES

Ongoing

Dr. Xiaodong Cheng, Emory University: PMID 17243178
Dr. Denis Grant, University of Toronto: PMID 17656365
Dr. Anthony Pegg , Pennsylvania State University College of Medicine: PMID 17585781, 18367445
Dr. Janet Thornton, European Bioinformatics Institute, Cambridge: PMID 17237076, 17425406