Leishmania donovani mitogen-activated protein kinase 3 (LdBPK_100540), kinase domain in complex with inhibitor NVP-BBT594

Target ID:

PP-MAPK3

Deposition Date:

Tuesday 17th December 2013

Families:

Protein Kinase

Related Diseases:

Parasitic disease

Structure type:

protein-ligand

Download Coordinates:

Authors:

Wernimont AK, Walker JR, Hutchinson A, Loppnau P, Edwards AM, Arrowsmith CH, Bountra C, Hui R, Mangos M

Site:

Toronto

4O2Z

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Structure Details

Trypanosoma and Leishmania parasites, similar to mammals but different from apicomplexan parasites, have a fully developed MAPK cascade. Specifically, their genomes contain up to 15 MAPKs, as well as MAPKK and MAPKKK members. We present herein the structure of Leishmania donovani MPK3 with the inhibitor NVP-BBT594, a known inhibitor of human non-receptor tyrosine kinase JAK2.