Crystal structure of MLLT1 (ENL) YEATS domain in complexed with compound 94 (a SGC iMLLT derivative)

Target ID:

MLLT1A

Deposition Date:

Tuesday 2nd October 2018

Families:

YEATS

Related Diseases:

Cancer and epigenetics

Structure type:

protein-ligand

Download Coordinates:

Authors:

Heidenreich, D., Chaikuad, A., Moustakim, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fedorov, O., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)

Site:

Frankfurt

6ht0

tabs

References

Discovery of an MLLT1/3 YEATS Domain Chemical Probe.

Moustakim, M., Christott, T., Monteiro, O.P., Bennett, J., Giroud, C., Ward, J., Rogers, C.M., Smith, P., Panagakou, I., Diaz-Saez, L., Felce, S.L., Gamble, V., Gileadi, C., Halidi, N., Heidenreich, D., Chaikuad, A., Knapp, S., Huber, K.V.M., Farnie, G., Heer, J., Manevski, N., Poda, G., Al-Awar, R., Dixon, D.J., Brennan, P.E., Fedorov, O.

(2018) Angew. Chem. Int. Ed. Engl. 57: 16302-16307

PubMed: 30288907