Epigenetic Mechanisms in Health and Disease

Gioacchino Natoli Ph.D.

Group Leader, Department of Experimental Oncology, European Institute of Oncology (IEO)

Gioacchino Natoli is a group leader at the Department of Experimental Oncology of the European Institute of Oncology (IEO) in Milan. Dr. Natoli obtained his MD degree and specialist training in Internal Medicine from the University of Rome. He then moved to basic research and joined the group of Michael Karin at UCSD for a postdoctoral training in 1998, working on NF-kB regulation of inflammation. In 2000 he moved to Switzerland (Institute for Research in Biomedicine) to run an independent research group and in 2005 he joined the IEO. The main research interest of Dr Natoli in the last years has been the regulation of inflammation and specifically chromatin-mediated control of inflammatory responses. Work form Natoli group has allowed identifying mechanisms controlling complex temporal patterns of inflammatory gene expression. More recent work has focused on the role of chromatin modifiers and particularly histone demethylases in inflammation.

Talk Title: "The epigenome and the control of inflammatory responses"