Biological integral membrane protein group of Toronto started in Phase II of SGC. This group is focusing on human membrane proteins which relate to our health. There are about 30% membrane proteins in human body representing ~60% of drug targets. The atomic structures of human membrane proteins are essential for understanding of molecular mechanism and function however not many structures have been solved.

Figure by Paxton Provitera
From: Charpter 1 of MEMBRANE PROTEIN STRUCTURE by Suzanne Scarlata

Specific goal

This group aims to establish a pipeline for structure determination of novel human membrane proteins.

Team Members

• Anling Kuo (In charge of the team)
• Haizhong Zhu
• Galina Khutoreskaya

Collaborated members

• Elena Dobrovetsky (Biotechnology)
• He Hao (Biotechnology)
• Guillermo Senisterra (Molecular Biophysics)
• Aiping Dong (Crystallography)